Hydrochloric Acid → HCID 178442191, compound

HRID 638583Notes

Reaction equation

HRID 638583 reaction equation
[CH3:1][N:2]1[C:7]([NH:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:14][C:13]=2[CH3:23])=[C:6]2[CH:24]=[CH:25][S:26][C:5]2=[N:4][CH2:3]1.[ClH:27]>C(O)C>[ClH:27].[CH3:1][N:2]1[C:7]([NH:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:14][C:13]=2[CH3:23])=[C:6]2[CH:24]=[CH:25][S:26][C:5]2=[N:4][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178442190HCID 178442190, compound

Product 1

HCID 178442191HCID 178442191, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5 g (0.0136 mole) of 3-methyl-4-[2-(2-methyl-4-pentylphenoxy)ethylamino]thieno[2,3-d]pyrimidine (Compound No. 15) were dissolved in 50 ml of ethanol, and 10 ml of concentrated hydrochloric acid were added at room temperature to the solution. The mixture was stirred for 10 minutes, after which the crystals which precipitated were collected by filtration and recrystallised from ethanol, giving 5.4 g (yield 98%) of the title compound in the form of colourless needles melting at 181°-183° C. This compound is identified in the Tables which follow as "15-HCl".

Workup

  1. customafter which the crystals which precipitated
  2. filtrationwere collected by filtration
  3. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-e34fb1e8b4784969a481ca4872e656f5
Source dataset
uspto-grants-1985_12
Patent number
US04562193

Reaction notes

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