反应详情

A solution of 2-acetoxymethyl-4-methoxypyridine (20.72 g, 0.114 mole) in 3M hydrochloric acid (100 ml) was heated under reflux for 1 hour. The resulting solution was concentrated under reduced pressure and the residue neutralised by addition of potassium carbonate. The mixture was extracted with dichloromethane and the organic solution dried over anhydrous sodium sulphate, filtered and evaporated to give a light coloured viscous oil which solidified on standing to yield the title compound (10.6 g, 67%) b.p. 135° C. at 0.1 mm mercury.

1. temperatureunder reflux for 1 hour
2. concentrationThe resulting solution was concentrated under reduced pressure
3. additionthe residue neutralised by addition of potassium carbonate
4. extractionThe mixture was extracted with dichloromethane
5. dry with materialthe organic solution dried over anhydrous sodium sulphate
6. filtrationfiltered
7. customevaporated
8. customto give a light