Hydrochloric Acid → HCID 54737984, compound

HRID 638598Notes

Reaction equation

HRID 638598 reaction equation
C[O:2][C:3](=[O:16])[CH2:4][C:5]1[C:12]2[NH:13][CH:14]=[CH:15][C:11]=2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.Cl>[OH-].[Na+]>[NH:13]1[CH:14]=[CH:15][C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=[C:5]([CH2:4][C:3]([OH:16])=[O:2])[C:12]1=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54730505HCID 54730505, compound3×

Product 1

HCID 54737984HCID 54737984, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A suspension of ±1H-cycloocta[b]pyrrole-9-acetic acid methyl ester, decahydro-2-oxo-, (3aα, 9β, 9aα)-; ±1H-cycloocta[b]pyrrole-9-acetic acid methyl ester, decahydro-2-oxo, (3aα, 9α, 9aα)-; 1H-cycloocta[b]pyrrole-9-acetic acid methyl ester, decahydro-2-oxo, (3 aα, 9β, 9aβ) - (3.0 g, 0.013 mol) in 2N NaOH (6.5 ml) is stirred until hydrolysis is complete. The basic solution is treated with 2N HCl (6.5 ml). The solution is cooled and the product is separated by filtration. After drying in vacuo ±1H-cycloocta[b]pyrrole-9-acetic acid, decahydro-2-oxo-, (3aα, 9β, 9aα)-; ±1H-cycloocta[b]pyrrole9-acetic acid, decahydro-2-oxo-, (3aα, 9α, 9aα)-; ±1H-cycloocta[b]pyrrole-9-acetic acid, decahydro-2-oxo(3aα, 9β, 9aβ)- are isolated as a crystalline solid.

Workup

  1. temperatureThe solution is cooled
  2. customthe product is separated by filtration
  3. dry with materialAfter drying in vacuo ±1H-cycloocta[b]pyrrole-9-acetic acid, decahydro-2-oxo-, (3aα, 9β, 9aα)-

Sources & evidence

ORD record
ord-29bbb37a0f564342a9333787b390cf4b
Source dataset
uspto-grants-1985_12
Patent number
US04562195

Reaction notes

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