反应详情

温度

10 °C

A mixture of 2-(4-Acetylaminophenoxy)propionic acid methyl ester 16 (320 grams, 1.35 mol) in concentrated hydrochloric acid (8 liters) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 17 (240 g, 81.7%) as a brown powder. The melting point was found to be 175-180° C.

1. temperaturewas refluxed for 48 hours
2. distillationExcess concentrated hydrochloric acid was distilled off in vacuum
3. filtrationfiltered hot
4. filtrationfiltered
5. customdried