反应详情

A mixture of methyl (4-nitrophenoxy)acetate 31 (100 g, 474 mmol) and concentrated HCl (1000 ml) was refluxed for 8 hours. The reaction mass was cooled to room temp. Crude 40 was filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:5) to give pure 40 (86 g, 92.1%) as a white shining powder. M.p: 186-188.5° C.

1. temperaturewas refluxed for 8 hours
2. filtrationCrude 40 was filtered
3. customdried
4. customrecrystallised from a mixture of ethyl acetate:hexane (1:5)