反应详情

A mixture of 2-(4-nitrophenoxy)propionic acid methyl ester 35 (50 g) and concentrated HCl (500 ml) was refluxed for 8 hours. The reaction mass was cooled to room temp. Crude 47 was filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:5) to give pure 47 (40 g, 85.3%) as a white powder. M.p: 139-141° C.

1. temperaturewas refluxed for 8 hours
2. filtrationCrude 47 was filtered
3. customdried
4. customrecrystallised from a mixture of ethyl acetate:hexane (1:5)