反应详情

A mixture of 6-(4-nitrophenoxy) hexanoic acid methyl ester 39 (125 g, 468.16 mmol) and concentrated HCl (1250 ml) was refluxed for 16 hours. The reaction mixture was cooled to room temperature, filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:6) to get pure 53 (95 g, 80.2%) as a white powder. M.p: 104-107° C.

1. temperaturewas refluxed for 16 hours
2. filtrationfiltered
3. customdried
4. customrecrystallised from a mixture of ethyl acetate:hexane (1:6)