huagongshe.com
HRID638821

反应详情

EQUATION

反应方程式

HRID 638821 的结构方程式

REACTANTS

反应物

2
结构：OB(O)c1ccncc1
HCID2734379

Pyridine-4-boronic acid

C5H6BNO2

结构：C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(Br)cc3)C[C@]2(C)[C@H]1C(=O)C1CC1
HCID68576237

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(-c4ccncc4)cc3)C[C@]2(C)[C@H]1C(=O)C1CC1
HCID44451341

未命名化合物

收率 44%

PROCEDURE

实验过程

(11β,16α,17β)-11-(4-Bromophenyl)-17-cyclopropylcarbonyl-16-methylestra-4,9-dien-3-one and 4-pyridinylboronic acid were applied as described in example 1 step h. Purification by HPLC followed by crystallisation (acetonitrile/water) gave the product (44% yield). 1H NMR (400 MHz, CDCl3): δ 0.33 (s, 3H), 0.84-2.85 (m, 24H), 4.46 (d, J=7 Hz, 1H), 5.81 (s, 1H), 7.26-7.30 (m, 2H), 7.48-7.50 (m, 2H), 7.55-7.59 (m, 2H), 8.63-8.65 (m, 2H).

WORKUP

后处理

  1. customPurification by HPLC
  2. customfollowed by crystallisation (acetonitrile/water)