(Pyridin-4-yl)boronic acid → (11beta,16alpha,17beta)-17-Cyclopropylcarbonyl-16-methyl-11-[4-(4-pyridinyl)phenyl]estra-4,9-dien-3-one

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Reaction Steps

(11β,16α,17β)-11-(4-Bromophenyl)-17-cyclopropylcarbonyl-16-methylestra-4,9-dien-3-one and 4-pyridinylboronic acid were applied as described in example 1 step h. Purification by HPLC followed by crystallisation (acetonitrile/water) gave the product (44% yield). 1H NMR (400 MHz, CDCl3): δ 0.33 (s, 3H), 0.84-2.85 (m, 24H), 4.46 (d, J=7 Hz, 1H), 5.81 (s, 1H), 7.26-7.30 (m, 2H), 7.48-7.50 (m, 2H), 7.55-7.59 (m, 2H), 8.63-8.65 (m, 2H).

Provenance & Evidence