2-Amino-6-methoxybenzothiazole → NSC697569

HRID 638839Notes

Reaction equation

HRID 638839 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]2[N:7]=[C:8]([NH2:10])[S:9][C:5]=2[CH:4]=1.Br[CH2:14][C:15](=O)[C:16]([O:18][CH2:19][CH3:20])=[O:17]>>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]2[N:7]3[CH:14]=[C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[N:10]=[C:8]3[S:9][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 156302-Amino-6-methoxybenzothiazoleHCID 66144Ethyl bromopyruvate

Product 1

HCID 394240NSC697569Yield 57.9%

Procedure

Ethyl 7-methoxyimidazo[2,1-b]-benzthiazole-2-carboxylate was prepared according to the procedure as outlined in Example 1, (Step 1). Starting from 6-methoxy-2-amino benzothiazole (27 g, 0.15 mol) and ethyl bromopyruvate (39.9 g, 0.2 mol), 24 g (43% Yield) of ethyl 7-methoxyimidazo[2,1-b]-benzthiazole-2-carboxylate was isolated as a brown solid. (M+H) 277.

Workup

  1. customEthyl 7-methoxyimidazo[2,1-b]-benzthiazole-2-carboxylate was prepared

Sources & evidence

ORD record
ord-a6df3ae70ed54d8790e229b6e79e2c27
Source dataset
uspto-grants-2010_04
Patent number
US07691842B2

Reaction notes

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