Potassium Carbonate → ethyl-5-[(2-oxocyclohexyl)oxy]-1H-pyrazole-3-carboxylate

HRID 638906Notes

Reaction equation

HRID 638906 reaction equation
[OH:1][C:2]1[NH:6][N:5]=[C:4]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Cl[CH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][C:20]1=[O:25]>C(#N)C>[CH2:10]([O:9][C:7]([C:4]1[CH:3]=[C:2]([O:1][CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][C:20]2=[O:25])[NH:6][N:5]=1)=[O:8])[CH3:11]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 132032-ChlorocyclohexanoneHCID 178469373HCID 178469373, compound

Product 1

HCID 178469286ethyl-5-[(2-oxocyclohexyl)oxy]-1H-pyrazole-3-carboxylateYield 49%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To the stirred suspension of ethyl 5-hydroxy-1H-pyrazole-3-carboxylate (6.25 g, 40 mmol) and 22.1 g of potassium carbonate in 500 ml of acetonitrile was added 6.35 g of 2-chlorocyclohexanone, and refluxed for 16 hours. The reaction mixture was allowed to cool to room temperature, then filtered, the solid was washed with acetonitrile. The filtrate was concentrated to an oil. The residue was dissolved in ethyl acetate and extracted with water. The organic phase was dried over MgSO4 and evaporated to dryness. The product was purified by silics-gel column chromatography by eluting it with 1:1 ethyl acetaet;hexane. 4.92 g (49%) of the desired product was obtained as a white solid. M.Pt. 122-124° C.; (M+H) 253.

Workup

  1. temperaturerefluxed for 16 hours
  2. filtrationfiltered
  3. washthe solid was washed with acetonitrile
  4. concentrationThe filtrate was concentrated to an oil
  5. dissolutionThe residue was dissolved in ethyl acetate
  6. extractionextracted with water
  7. dry with materialThe organic phase was dried over MgSO4
  8. customevaporated to dryness
  9. customThe product was purified by silics-gel column chromatography
  10. washby eluting it with 1:1 ethyl acetaet

Sources & evidence

ORD record
ord-5812e41d0f594f60a22ebfbcc6bfb448
Source dataset
uspto-grants-2010_04
Patent number
US07691842B2

Reaction notes

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