Benzyl Bromide → 3-[3-(Benzyloxy)propyl]-4,5-dimethoxybenzoic acid

HRID 638915Notes

Reaction equation

HRID 638915 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15])[C:8]([OH:10])=[O:9].[CH2:18](Br)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:18]([O:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15])[C:8]([OH:10])=[O:9])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 686851493-(3-Hydroxypropyl)-4,5-dimethoxybenzoic acid

Product 1

HCID 686829003-[3-(Benzyloxy)propyl]-4,5-dimethoxybenzoic acidYield 68%

Procedure

3-(3-Benzyloxypropyl)-4,5-dimethoxybenzoic acid was prepared from 3,4-dimethoxy-5-hydroxypropylbenzoic acid (Example 10, Step 1) and benzyl bromide in 68% yield by following Method I and used without further purification.

Workup

  1. customused without further purification

Sources & evidence

ORD record
ord-dc1f37d91f71437cb7c33df8e55b9e81
Source dataset
uspto-grants-2010_04
Patent number
US07691843B2

Reaction notes

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