Methyl iodide → 2-(Trifluoromethoxy)anisole

HRID 638923Notes

Reaction equation

HRID 638923 reaction equation
[F:1][C:2]([F:12])([F:11])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10].[CH3:13]I>>[F:1][C:2]([F:11])([F:12])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[O:10][CH3:13]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 27772992-(Trifluoromethoxy)phenol

Product 1

HCID 27771852-(Trifluoromethoxy)anisoleYield 78%

Procedure

2-Trifluoromethoxyanisole was prepared from 2-trifluoromethoxyphenol by following Method C in 78% yield. Methyl iodide was used in this reaction as an alkylating agent and the reaction was conducted at room temperature for 17 h. The product was used without further purification.

Workup

  1. customThe product was used without further purification

Sources & evidence

ORD record
ord-76282cb9be344f6484b9ec6a540b1468
Source dataset
uspto-grants-2010_04
Patent number
US07691843B2

Reaction notes

Loading…