Methyl iodide → 3,4-Dimethoxy-5-(3-methoxypropyl)benzoic acid

HRID 638926Notes

Reaction equation

HRID 638926 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15])[C:8]([OH:10])=[O:9].[CH3:18]I>>[CH3:17][O:16][C:12]1[CH:11]=[C:7]([CH:6]=[C:5]([CH2:4][CH2:3][CH2:2][O:1][CH3:18])[C:13]=1[O:14][CH3:15])[C:8]([OH:10])=[O:9]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 686851493-(3-Hydroxypropyl)-4,5-dimethoxybenzoic acid

Product 1

HCID 686852153,4-Dimethoxy-5-(3-methoxypropyl)benzoic acidYield 69%

Procedure

3,4-Dimethoxy-5-(3-methoxypropyl)benzoic acid was prepared from 3-(3-hydroxypropyl)-4,5-Dimethoxybenzoic acid (Example 10, Step 1) and methyl iodide by following Method I in 69% yield. The product was used without further purification.

Workup

  1. customThe product was used without further purification

Sources & evidence

ORD record
ord-d776a3b544fa46b7a1e597b665a71539
Source dataset
uspto-grants-2010_04
Patent number
US07691843B2

Reaction notes

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