Ethyl Bromide → 3-(3-Ethoxypropyl)-4,5-dimethoxybenzoic acid

HRID 638927Notes

Reaction equation

HRID 638927 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15])[C:8]([OH:10])=[O:9].[CH2:18](Br)[CH3:19]>>[CH2:18]([O:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15])[C:8]([OH:10])=[O:9])[CH3:19]

Participants

3

Reactant 2

HCID 6332Ethyl BromideHCID 686851493-(3-Hydroxypropyl)-4,5-dimethoxybenzoic acid

Product 1

HCID 686852963-(3-Ethoxypropyl)-4,5-dimethoxybenzoic acidYield 72%

Procedure

3-(3-Ethoxypropyl)-4,5-dimethoxybenzoic acid was prepared from 3-(3-hydroxypropyl)-4,5-Dimethoxybenzoic acid (Example 10, Step 1) and ethyl bromide by following Method I in 72% yield. The product was used without further purification.

Workup

  1. customThe product was used without further purification

Sources & evidence

ORD record
ord-2feb32446fe04d3da928a8ca6abbf669
Source dataset
uspto-grants-2010_04
Patent number
US07691843B2

Reaction notes

Loading…