Methyl iodide → HCID 68683485, compound

HRID 638928Notes

Reaction equation

HRID 638928 reaction equation
[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([OH:12])=[C:6]([CH2:13][CH:14]=[CH2:15])[CH:5]=1.[CH3:17]I>>[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([O:12][CH3:17])=[C:6]([CH2:13][CH:14]=[CH2:15])[CH:5]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 7131942methyl 3-allyl-4-hydroxy-5-methoxybenzoate

Product 1

HCID 68683485HCID 68683485, compoundYield 96%

Procedure

3-Allyl-4,5-dimethoxybenzoic acid methyl ester was prepared from 3-allyl-4-hydroxy-5-methoxybenzoic acid methyl ester (Example 1, Step 2) by following Method C using methyl iodide as alkylating agent. The reaction was conducted at room temperature for 16 h and crude product was purified by flash column chromatography (96% yield).

Workup

  1. customcrude product was purified by flash column chromatography (96% yield)

Sources & evidence

ORD record
ord-ecbe9b079b2447e4a1c9cd9d8e58b046
Source dataset
uspto-grants-2010_04
Patent number
US07691843B2

Reaction notes

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