1,1,1-Trifluoro-2-iodoethane → Methyl 3-[(2,2,2-trifluoroethyl)sulfanyl]benzoate

HRID 638948Notes

Reaction equation

HRID 638948 reaction equation
[CH3:1][O:2][C:3](=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([SH:10])[CH:5]=1.[F:12][C:13]([F:17])([F:16])[CH2:14]I>>[CH3:1][O:2][C:3](=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([S:10][CH2:14][C:13]([F:17])([F:16])[F:12])[CH:5]=1

Participants

3

Reactant 2

HCID 677091,1,1-Trifluoro-2-iodoethaneHCID 4362804Methyl 3-mercaptobenzoate

Product 1

HCID 68684094Methyl 3-[(2,2,2-trifluoroethyl)sulfanyl]benzoateYield 82%

Procedure

3-(2,2,2-Trifluoroethylthio)benzoic acid methyl ester was prepared 3-mercaptobenzoic acid methyl ester and trifluoroethyl iodide by following Method C. The reaction was conducted at room temperature overnight. The crude residue was chromatographed in 10-20% EtOAc/hexanes to afford 3-(2,2,2-trifluoroethylthio)benzoic acid methyl ester (82% yield).

Workup

  1. customThe crude residue was chromatographed in 10-20% EtOAc/hexanes

Sources & evidence

ORD record
ord-158d5743fcc84cc4883141f7e7f700e3
Source dataset
uspto-grants-2010_04
Patent number
US07691843B2

Reaction notes

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