HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1,1-Trifluoro-2-iodoethane → Methyl 3-[(2,2,2-trifluoroethyl)sulfanyl]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1,1-Trifluoro-2-iodoethane | HCID 67709 | — |
| Reactant | Methyl 3-mercaptobenzoate | HCID 4362804 | — |
| Product | Methyl 3-[(2,2,2-trifluoroethyl)sulfanyl]benzoate | HCID 68684094 | 82% |
Reaction Steps
3-(2,2,2-Trifluoroethylthio)benzoic acid methyl ester was prepared 3-mercaptobenzoic acid methyl ester and trifluoroethyl iodide by following Method C. The reaction was conducted at room temperature overnight. The crude residue was chromatographed in 10-20% EtOAc/hexanes to afford 3-(2,2,2-trifluoroethylthio)benzoic acid methyl ester (82% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07691843B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-158d5743fcc84cc4883141f7e7f700e3 |
| Source note | uspto-grants-2010_04 |