HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 4-(Benzyloxy)-3-(trifluoromethoxy)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1-(Benzyloxy)-4-bromo-2-(trifluoromethoxy)benzene | HCID 68686500 | — |
| Product | 4-(Benzyloxy)-3-(trifluoromethoxy)benzoic acid | HCID 68685671 | — |
Reaction Steps
4-Benzyloxy-3-trifluoromethoxybenzoic acid was prepared from 4-benzyloxy-1-bromo-3-trifluoromethoxybenzene by following Method M. The crude product was purified by crystallization using a mixture of EtOAc and hexanes as a solvent (19% yield of desired product from the first crop).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07691843B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-2c293002c18f4882888530ff979cff96 |
| Source note | uspto-grants-2010_04 |