Ethyl Acetate → 4-(Benzyloxy)-3-(trifluoromethoxy)benzoic acid

HRID 638952Notes

Reaction equation

HRID 638952 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12](Br)=[CH:11][C:10]=1[O:16][C:17]([F:20])([F:19])[F:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CC[O:23][C:24](C)=[O:25]>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:24]([OH:25])=[O:23])=[CH:11][C:10]=1[O:16][C:17]([F:20])([F:19])[F:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 8857Ethyl AcetateHCID 686865001-(Benzyloxy)-4-bromo-2-(trifluoromethoxy)benzene

Product 1

HCID 686856714-(Benzyloxy)-3-(trifluoromethoxy)benzoic acid

Procedure

4-Benzyloxy-3-trifluoromethoxybenzoic acid was prepared from 4-benzyloxy-1-bromo-3-trifluoromethoxybenzene by following Method M. The crude product was purified by crystallization using a mixture of EtOAc and hexanes as a solvent (19% yield of desired product from the first crop).

Workup

  1. customThe crude product was purified by crystallization

Sources & evidence

ORD record
ord-2c293002c18f4882888530ff979cff96
Source dataset
uspto-grants-2010_04
Patent number
US07691843B2

Reaction notes

Loading…