Benzyl Bromide → 1-(Benzyloxy)-4-bromo-2-[(trifluoromethyl)sulfanyl]benzene

Participants

Reaction Steps

1-Benzyloxy-4-bromo-2-trifluoromethylthiobenzene was prepared from 4-bromo-1-hydroxy-2-trifluoromethylthiobenzene following Method C. The reaction was conducted at 50° C. for 1 h using benzyl bromide as an alkylating agent and the resulting product was purified by column chromatography using hexanes as an eluent to afford 1-benzyloxy-4-bromo-2-trifluoromethylthiobenzene in 63% yield.

Provenance & Evidence