Benzyl Bromide → 1-(Benzyloxy)-4-bromo-2-[(trifluoromethyl)sulfanyl]benzene

HRID 638954Notes

Reaction equation

HRID 638954 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([S:9][C:10]([F:13])([F:12])[F:11])[CH:3]=1.[CH2:14](Br)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH2:14]([O:8][C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][C:4]=1[S:9][C:10]([F:13])([F:11])[F:12])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 686856734-Bromo-2-[(trifluoromethyl)sulfanyl]phenol

Product 1

HCID 686868611-(Benzyloxy)-4-bromo-2-[(trifluoromethyl)sulfanyl]benzene

Procedure

1-Benzyloxy-4-bromo-2-trifluoromethylthiobenzene was prepared from 4-bromo-1-hydroxy-2-trifluoromethylthiobenzene following Method C. The reaction was conducted at 50° C. for 1 h using benzyl bromide as an alkylating agent and the resulting product was purified by column chromatography using hexanes as an eluent to afford 1-benzyloxy-4-bromo-2-trifluoromethylthiobenzene in 63% yield.

Workup

  1. customthe resulting product was purified by column chromatography

Sources & evidence

ORD record
ord-9062141baf054398915a59a2aed7b2d4
Source dataset
uspto-grants-2010_04
Patent number
US07691843B2

Reaction notes

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