反应详情

3-(3-Fluorophenylethynyl)-4,5-dimethoxybenzoic acid was prepared by coupling 1-ethynyl-3-fluorobenzene with 3-iodo-4,5-dimethoxybenzoic acid Method R. The crude product was purified via flash column chromatography on silica gel (5% MeOH in CH2Cl2 as an eluent) to give 3-(3-fluorophenylethynyl)-4,5-dimethoxybenzoic acid in 95% yield. ESMS: m/z 299.3 [M−H].

1. custom3-(3-Fluorophenylethynyl)-4,5-dimethoxybenzoic acid was prepared
2. customThe crude product was purified via flash column chromatography on silica gel (5% MeOH in CH2Cl2 as an eluent)