HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Iodo-4,5-dimethoxybenzoic acid → 3-[(3-Fluorophenyl)ethynyl]-4,5-dimethoxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Iodo-4,5-dimethoxybenzoic acid | HCID 230459 | — |
| Reactant | 1-Ethynyl-3-fluorobenzene | HCID 520218 | — |
| Product | 3-[(3-Fluorophenyl)ethynyl]-4,5-dimethoxybenzoic acid | HCID 68686157 | — |
Reaction Steps
3-(3-Fluorophenylethynyl)-4,5-dimethoxybenzoic acid was prepared by coupling 1-ethynyl-3-fluorobenzene with 3-iodo-4,5-dimethoxybenzoic acid Method R. The crude product was purified via flash column chromatography on silica gel (5% MeOH in CH2Cl2 as an eluent) to give 3-(3-fluorophenylethynyl)-4,5-dimethoxybenzoic acid in 95% yield. ESMS: m/z 299.3 [M−H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07691843B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-b32646cef7314f0090843736b803e58a |
| Source note | uspto-grants-2010_04 |