Trifluoroacetic acid → HCID 68576477, compound

HRID 638993Notes

Reaction equation

HRID 638993 reaction equation
CC([N:5]([C:9]1[CH:10]=[N:11][C:12]2[C:17]([C:18]=1[Br:19])=[CH:16][C:15]([O:20][CH3:21])=[CH:14][C:13]=2[F:22])C(=O)[O-])(C)C.FC(F)(F)C(O)=O>ClCCl>[Br:19][C:18]1[C:17]2[C:12](=[C:13]([F:22])[CH:14]=[C:15]([O:20][CH3:21])[CH:16]=2)[N:11]=[CH:10][C:9]=1[NH2:5]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86616782HCID 86616782, compound

Product 1

HCID 68576477HCID 68576477, compoundYield 100.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1,1-Dimethylethyl[4-bromo-8-fluoro-6-(methoxy)-3-quinolinyl]carbamate (6.4 g, 17.3 mmol)) was treated with trifluoroacetic acid (50 ml) in dichloromethane (50 ml) at room temperature for two hours then evaporated to dryness. The residue was basified with sodium bicarbonate. A precipitate was formed which was filtered and dried in vacuo to afford the product as a white solid (4.7 g, 100%). MS (+ve ion electrospray) m/z 272 (MH+).

Workup

  1. customthen evaporated to dryness
  2. customA precipitate was formed which
  3. filtrationwas filtered
  4. customdried in vacuo

Sources & evidence

ORD record
ord-1e2269eb00e64078b2b9ab2f068c530c
Source dataset
uspto-grants-2010_04
Patent number
US07691850B2

Reaction notes

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