HRID638996

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8113

Diethanolamine

C4H11NO2

HCID21948949

未命名化合物

结构：C[C@@H]1[C@@H](B(Cl)[C@H]2C[C@@H]3C[C@@H]([C@@H]2C)C3(C)C)C[C@@H]2C[C@H]1C2(C)C

HCID91873398

未命名化合物

PRODUCTS

生成物

HCID23400264

未命名化合物

收率 73%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

Bromomethyl-(6-methoxy-[1,5]-naphthyridin-4-yl)-ketone (6.6 g, 0.023 mol) in toluene was treated with (+)-B-chlorodiisopinocamphenylborane ((+)-DIP-chloride) (12 g, 0.037 mol) and stirred overnight, then diethanolamine (15 g, 0.14 mol) added and the mixture stirred for 3 hours, filtered and evaporated. Chromatography on silica gel (ethyl acetate-hexane) gave a white solid (4.73 g, 73%).

WORKUP

后处理

stirringthe mixture stirred for 3 hours
filtrationfiltered
customevaporated