HCID 68577438, compound → 6-(Hydroxymethyl)-4-mercaptopyridin-3-ol

HRID 639037Notes

Reaction equation

HRID 639037 reaction equation
C([O:4][CH2:5][C:6]1[CH:11]=[C:10]([S:12]C(C)(C)C)[C:9]([OH:17])=[CH:8][N:7]=1)(=O)C>Cl>[OH:4][CH2:5][C:6]1[N:7]=[CH:8][C:9]([OH:17])=[C:10]([SH:12])[CH:11]=1

Participants

3

Reactant 1

HCID 68577438HCID 68577438, compound

Product 1

HCID 1785197826-(Hydroxymethyl)-4-mercaptopyridin-3-olYield 88%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
80 °C

Procedure

{4-[(1,1-dimethylethyl)thio]-5-hydroxy-2-pyridinyl}methyl acetate (2.5 g, 9.8 mmol) was dissolved in concentrated HCl and the mixture was heated at 80° C. for 18 hours. The solvent was evaporated under vacuum and the residue was triturated with diethyl ether to afford the product as a solid (1.35 g, 88%); MS (+ve ion electrospray) m/z 158 (MH+).

Workup

  1. customThe solvent was evaporated under vacuum
  2. customthe residue was triturated with diethyl ether

Sources & evidence

ORD record
ord-f23a8eee1ff24bcd9621e1c8230efd84
Source dataset
uspto-grants-2010_04
Patent number
US07691850B2

Reaction notes

Loading…