Hydrochloric Acid → HCID 59026154, compound

HRID 639111Notes

Reaction equation

HRID 639111 reaction equation
CC([N:5]([C:9]([C@H:12]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C:19]2[C:28]3[C:23](=[CH:24][CH:25]=[C:26]([O:29][CH3:30])[N:27]=3)[N:22]=[CH:21][C:20]=2[F:31])[CH2:13]1)([CH3:11])[CH3:10])C(=O)[O-])(C)C.Cl>C(Cl)Cl>[F:31][C:20]1[CH:21]=[N:22][C:23]2[C:28]([C:19]=1[CH2:18][CH2:17][N:14]1[CH2:15][CH2:16][C@@H:12]([C:9]([NH2:5])([CH3:11])[CH3:10])[CH2:13]1)=[N:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86616809HCID 86616809, compound

Product 1

HCID 59026154HCID 59026154, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1,1-dimethylethyl[1-((3S)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)-1-methylethyl]carbamate (0.46 g, 1.06 mmol) in DCM (10 mL) at 25° C. was added dropwise an HCl solution (4.22 mL, 4.24 mmol, 1M HCl in dioxane). After 24 h, the solution was concentrated to afford the hydrochloride salt of the title compound as an off-white residue (0.43 g, quantit.), which was used without further purification: LC/MS (ES) m/e 333 (M+H)+.

Workup

  1. concentrationthe solution was concentrated

Sources & evidence

ORD record
ord-c582afd58a6b43fcba4a6d6e44b55600
Source dataset
uspto-grants-2010_04
Patent number
US07691850B2

Reaction notes

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