Hydrochloric Acid → HCID 68805425, compound

HRID 639130Notes

Reaction equation

HRID 639130 reaction equation
CC([N:5]([CH2:9][C@H:10]1[C@H:14]([C:15]([NH2:17])=[O:16])[CH2:13][N:12]([CH2:18][CH2:19][C:20]2[C:29]3[C:24](=[CH:25][CH:26]=[C:27]([O:30][CH3:31])[N:28]=3)[N:23]=[CH:22][C:21]=2[F:32])[CH2:11]1)C(=O)[O-])(C)C.Cl.O1CCOCC1>C(Cl)Cl>[NH2:5][CH2:9][C@@H:10]1[CH2:11][N:12]([CH2:18][CH2:19][C:20]2[C:29]3[C:24](=[CH:25][CH:26]=[C:27]([O:30][CH3:31])[N:28]=3)[N:23]=[CH:22][C:21]=2[F:32])[CH2:13][C@@H:14]1[C:15]([NH2:17])=[O:16]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 86616817HCID 86616817, compound

Product 1

HCID 68805425HCID 68805425, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1,1-dimethylethyl[((3S,4S)-4-(aminocarbonyl)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]carbamate (0.51 g, 1.14 mmol) was dissolved in methylene chloride (5 mL). HCl in dioxane (2.87 mL, 11.14 mmol) was added and the solution stirred at ambient temperature for 2 hours. The solvent was removed under reduced pressure. (0.534 g, quant.) LCMS: m/z 348.4 (MH+).

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-80116a3be93f469586587e435403efd3
Source dataset
uspto-grants-2010_04
Patent number
US07691850B2

Reaction notes

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