Hydrochloric Acid → HCID 59026159, compound

HRID 639132Notes

Reaction equation

HRID 639132 reaction equation
[OH:1][C@H:2]1[C@@H:6]([CH2:7][NH:8][C:9](=[O:14])[C:10]([F:13])([F:12])[F:11])[CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.Cl.O1CCOCC1>C(Cl)Cl>[F:13][C:10]([F:11])([F:12])[C:9]([NH:8][CH2:7][C@@H:6]1[C@H:2]([OH:1])[CH2:3][NH:4][CH2:5]1)=[O:14]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 590261131,1-Dimethylethyl (3S,4S)-3-hydroxy-4-[[(2,2,2-trifluoroacetyl)amino]methyl]-1-pyrrolidinecarboxylate

Product 1

HCID 59026159HCID 59026159, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(1,1-dimethylethyl(3S,4S)-3-hydroxy-4-{[(trifluoroacetyl)amino]methyl}-1-pyrrolidinecarboxylate (0.192 g, 0.615 mmol) was dissolved in methylene chloride (5 mL). HCl in dioxane (1.0 mL, 4.0 mmol) was added and the solution stirred at ambient temperature for 2 hours. The solvent was removed under reduced pressure. (0.137 g, quant.) LCMS: m/z 213.2 (MH+).

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-1d94b506e4e54df5b517cd237cf2493c
Source dataset
uspto-grants-2010_04
Patent number
US07691850B2

Reaction notes

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