Ethyl cyanoacetate → 2-cyano-N-(2-methoxyethyl)acetamide

HRID 639143Notes

Reaction equation

HRID 639143 reaction equation
[C:1]([CH2:3][C:4]([O:6]CC)=O)#[N:2].[CH3:9][O:10][CH2:11][CH2:12][NH2:13]>C(O)C>[C:1]([CH2:3][C:4]([NH:13][CH2:12][CH2:11][O:10][CH3:9])=[O:6])#[N:2]

Participants

4

Reactant 2

HCID 7764Ethyl cyanoacetateHCID 80182-Methoxyethylamine

Product 1

HCID 16438552-cyano-N-(2-methoxyethyl)acetamide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.5 g (4.42 mmol) Ethyl cyanoacetate and 0.37 g (4.86 mmol) 2-methoxyethylamine are dissolved in 10 ml ethanol and stirred at reflux overnight. After cooling down to room temperature, the solvent is removed in vacuo and the product is crystallised from ethanol/diethylether.

Workup

  1. temperatureat reflux overnight
  2. customthe solvent is removed in vacuo
  3. customthe product is crystallised from ethanol/diethylether

Sources & evidence

ORD record
ord-7cfbd73ec4d34dc380ac579d243f96ea
Source dataset
uspto-grants-2010_04
Patent number
US07691854B2

Reaction notes

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