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Piperidine → HCID 178467230、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 4-Cyanobenzaldehyde | HCID 66042 | — |
| 反応物 | 5-Methylisoxazole | HCID 79833 | — |
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 反応物 | 3-{[3-(Trifluoromethyl)phenyl]amino}but-2-enenitrile | HCID 5075287 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | HCID 178467230 | HCID 178467230 | — |
反応手順
Under argon, 100 mg (1.20 mmol) 5-methylisoxazole are dissolved in 2 ml ethanol and 81.90 mg (1.20 mmol) sodium ethanolate are added. The mixture is stirred at room temperature for one hour. Then 272.24 mg (1.20 mmol) of the compound of Example 2A, 157.82 mg (1.20 mmol) 4-formylbenzonitrile and 10.25 mg (11.90 μl, 0.12 mmol) piperidine are added to the mixture which is stirred at reflux overnight. After the reaction is finished, the mixture is purified by preparative HPLC.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07691854B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-5987c91bd2a2434486cda19897fc2df6 |
| 出典メモ | uspto-grants-2010_04 |