HRID639229

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID31160

4-Phenylbutan-2-amine

C10H15N

结构：Cc1ccccc1-c1ccc(C(=O)N2Cc3ccc(C(=O)C(Cl)(Cl)Cl)n3Cc3ccccc32)cc1C

HCID16038471

未命名化合物

PRODUCTS

生成物

结构：Cc1ccccc1-c1ccc(C(=O)N2Cc3ccc(C(=O)NC(C)CCc4ccccc4)n3Cc3ccccc32)cc1C

HCID16038754

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in the manner of Example 13 from 2,2,2-trichloro-1-{10-[(2,2′-dimethyl-1,1′-biphenyl-4-yl)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone of Example 6 and 1-methyl-3-phenylpropylamine, m.p. 152-154° C. MS [(+)ESI, m/z]: 566 [M+H]+ Anal. Calcd for C36H37N3O2: C, 80.39; H, 6.57; N, 7.40. Found: C, 80.27; H, 6.70; N, 7.27.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a8b6814e3333456caa7df5c78c2de570
来源数据集: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07691848B2
来源说明: uspto-grants-2010_04

反应 SMILES

ClC(Cl)(Cl)[C:3]([C:5]1[N:14]2[C:8]([CH2:9][N:10]([C:19]([C:21]3[CH:26]=[CH:25][C:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[CH3:33])=[C:23]([CH3:34])[CH:22]=3)=[O:20])[C:11]3[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=3[CH2:13]2)=[CH:7][CH:6]=1)=[O:4].[CH3:37][CH:38]([NH2:47])[CH2:39][CH2:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1>>[CH3:34][C:23]1[CH:22]=[C:21]([C:19]([N:10]2[C:11]3[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=3[CH2:13][N:14]3[C:5]([C:3]([NH:47][CH:38]([CH3:37])[CH2:39][CH2:40][C:41]4[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=4)=[O:4])=[CH:6][CH:7]=[C:8]3[CH2:9]2)=[O:20])[CH:26]=[CH:25][C:24]=1[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[CH3:33]