Triethylamine → HCID 16038755, compound

HRID 639230Notes

Reaction equation

HRID 639230 reaction equation
ClC(Cl)(Cl)[C:3]([C:5]1[N:14]2[C:8]([CH2:9][N:10]([C:19]([C:21]3[CH:26]=[CH:25][C:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[CH3:33])=[C:23]([CH3:34])[CH:22]=3)=[O:20])[C:11]3[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=3[CH2:13]2)=[CH:7][CH:6]=1)=[O:4].Cl.[CH2:38]1[O:49][C:48]2[CH:47]=[CH:46][C:42]([CH2:43][CH2:44][NH2:45])=[CH:41][C:40]=2[O:39]1.C(N(CC)CC)C>>[O:49]1[C:48]2[CH:47]=[CH:46][C:42]([CH2:43][CH2:44][NH:45][C:3]([C:5]3[N:14]4[C:8]([CH2:9][N:10]([C:19]([C:21]5[CH:26]=[CH:25][C:24]([C:27]6[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=6[CH3:33])=[C:23]([CH3:34])[CH:22]=5)=[O:20])[C:11]5[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=5[CH2:13]4)=[CH:7][CH:6]=3)=[O:4])=[CH:41][C:40]=2[O:39][CH2:38]1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 742461,3-Benzodioxole-5-ethanamine, hydrochloride (1:1)HCID 160384712,2,2-Trichloro-1-{10-[(2,2'-dimethyl-1,1'-biphenyl-4-yl)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone

Product 1

HCID 16038755HCID 16038755, compound

Procedure

The title compound was synthesized in the manner of Example 13 from 2,2,2-trichloro-1-{10-[(2,2′-dimethyl-1,1′-biphenyl-4-yl)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone of Example 6, 3,4-methylenedioxyphenethylamine hydrochloride and triethylamine (2.2 eq.), m.p. 154-157° C. MS [(+)ESI, m/z]: 582 [M+H]+

Sources & evidence

ORD record
ord-58fb3ac55ea1470e8ceda2db479703e1
Source dataset
uspto-grants-2010_04
Patent number
US07691848B2

Reaction notes

Loading…