HRID639230

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID74246

Phenethylamine, 3,4-methylenedioxy-, hydrochloride

C9H12ClNO2

结构：Cc1ccccc1-c1ccc(C(=O)N2Cc3ccc(C(=O)C(Cl)(Cl)Cl)n3Cc3ccccc32)cc1C

HCID16038471

未命名化合物

PRODUCTS

生成物

结构：Cc1ccccc1-c1ccc(C(=O)N2Cc3ccc(C(=O)NCCc4ccc5c(c4)OCO5)n3Cc3ccccc32)cc1C

HCID16038755

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in the manner of Example 13 from 2,2,2-trichloro-1-{10-[(2,2′-dimethyl-1,1′-biphenyl-4-yl)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone of Example 6, 3,4-methylenedioxyphenethylamine hydrochloride and triethylamine (2.2 eq.), m.p. 154-157° C. MS [(+)ESI, m/z]: 582 [M+H]+

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-58fb3ac55ea1470e8ceda2db479703e1
来源数据集: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07691848B2
来源说明: uspto-grants-2010_04

反应 SMILES

ClC(Cl)(Cl)[C:3]([C:5]1[N:14]2[C:8]([CH2:9][N:10]([C:19]([C:21]3[CH:26]=[CH:25][C:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[CH3:33])=[C:23]([CH3:34])[CH:22]=3)=[O:20])[C:11]3[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=3[CH2:13]2)=[CH:7][CH:6]=1)=[O:4].Cl.[CH2:38]1[O:49][C:48]2[CH:47]=[CH:46][C:42]([CH2:43][CH2:44][NH2:45])=[CH:41][C:40]=2[O:39]1.C(N(CC)CC)C>>[O:49]1[C:48]2[CH:47]=[CH:46][C:42]([CH2:43][CH2:44][NH:45][C:3]([C:5]3[N:14]4[C:8]([CH2:9][N:10]([C:19]([C:21]5[CH:26]=[CH:25][C:24]([C:27]6[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=6[CH3:33])=[C:23]([CH3:34])[CH:22]=5)=[O:20])[C:11]5[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=5[CH2:13]4)=[CH:7][CH:6]=3)=[O:4])=[CH:41][C:40]=2[O:39][CH2:38]1