4-(Trifluoromethoxy)benzylamine → 10-[(2-Methoxy-2'-methyl-1,1'-biphenyl-4-YL)carbonyl]-N-[4-(trifluoromethoxy)benzyl]-10,11-dihydro-5H-pyrrolo[2,1-C][1,4]benzodiazepine-3-carboxamide

HRID 639247노트

반응식

HRID 639247 반응식
ClC(Cl)(Cl)[C:3]([C:5]1[N:14]2[C:8]([CH2:9][N:10]([C:19]([C:21]3[CH:26]=[CH:25][C:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[CH3:33])=[C:23]([O:34][CH3:35])[CH:22]=3)=[O:20])[C:11]3[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=3[CH2:13]2)=[CH:7][CH:6]=1)=[O:4].[F:38][C:39]([F:50])([F:49])[O:40][C:41]1[CH:48]=[CH:47][C:44]([CH2:45][NH2:46])=[CH:43][CH:42]=1>>[CH3:35][O:34][C:23]1[CH:22]=[C:21]([C:19]([N:10]2[C:11]3[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=3[CH2:13][N:14]3[C:5]([C:3]([NH:46][CH2:45][C:44]4[CH:47]=[CH:48][C:41]([O:40][C:39]([F:49])([F:50])[F:38])=[CH:42][CH:43]=4)=[O:4])=[CH:6][CH:7]=[C:8]3[CH2:9]2)=[O:20])[CH:26]=[CH:25][C:24]=1[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[CH3:33]

참가 물질

3

반응물 2

HCID 5718464-(Trifluoromethoxy)benzylamineHCID 160388252,2,2-Trichloro-1-{10-[(2-methoxy-2'-methyl-1,1'-biphenyl-4-yl)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone

생성물 1

HCID 1603890210-[(2-Methoxy-2'-methyl-1,1'-biphenyl-4-YL)carbonyl]-N-[4-(trifluoromethoxy)benzyl]-10,11-dihydro-5H-pyrrolo[2,1-C][1,4]benzodiazepine-3-carboxamide

실험 절차

The title compound was prepared in the manner of Example 36 from 2,2,2-trichloro-1-{10-[(2-methoxy-2′-methyl-1,1′-biphenyl-4-yl)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone of Example 35 and 4-trifluoromethoxybenzylamine, m.p. 145-149° C. MS [(+)ESI, m/z]: 626 [M+H]+ Anal. Calcd for C36H30F3N3O4: C, 69.11; H, 4.83; N, 6.72. Found: C, 69.08; H, 4.95; N, 6.53.

출처 및 근거

ORD 기록
ord-77877d4dea1a4e75910a8434b081ecfb
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691848B2

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