4-(Trifluoromethoxy)benzylamine → 10-[(2-Methoxy-2'-methyl-1,1'-biphenyl-4-YL)carbonyl]-N-[4-(trifluoromethoxy)benzyl]-10,11-dihydro-5H-pyrrolo[2,1-C][1,4]benzodiazepine-3-carboxamide

Participants

Reaction Steps

The title compound was prepared in the manner of Example 36 from 2,2,2-trichloro-1-{10-[(2-methoxy-2′-methyl-1,1′-biphenyl-4-yl)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone of Example 35 and 4-trifluoromethoxybenzylamine, m.p. 145-149° C. MS [(+)ESI, m/z]: 626 [M+H]+ Anal. Calcd for C36H30F3N3O4: C, 69.11; H, 4.83; N, 6.72. Found: C, 69.08; H, 4.95; N, 6.53.

Provenance & Evidence