反应详情

The title compound was prepared in the manner of Example 36 from 2,2,2-trichloro-1-{10-[(2-methoxy-2′-methyl-1,1′-biphenyl-4-yl)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone of Example 35 and (4-aminomethylphenyl)-dimethylamine dihydrochloride in the presence of two equivalents of triethylamine. Purification was performed using HPLC with a normal phase column. Elution with a mixture of etoxynonafluorobutane and methanol gave the title compound in 37% yield, m.p. 148-150° C. MS [(+)ESI, m/z]: 585 [M+H]+

1. customPurification
2. washElution
3. additionwith a mixture of etoxynonafluorobutane and methanol