HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethylamine → 10-[(4-Chloro-2-methylphenoxy)acetyl]-N-(4-hydroxy-3-methoxybenzyl)-10,11-dihydro-5H-pyrrolo[2,1-C][1,4]benzodiazepine-3-carboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | Phenol, 4-(aminomethyl)-2-methoxy-, hydrochloride (1:1) | HCID 165576 | — |
| Edukt | 2,2,2-Trichloro-1-{10-[(4-chloro-2-methylphenoxy)acetyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone | HCID 16039295 | — |
| Produkt | 10-[(4-Chloro-2-methylphenoxy)acetyl]-N-(4-hydroxy-3-methoxybenzyl)-10,11-dihydro-5H-pyrrolo[2,1-C][1,4]benzodiazepine-3-carboxamide | HCID 16039365 | — |
Reaktionsschritte
The title compound was synthesized from 2,2,2-trichloro-1-{10-[(4-chloro-2-methylphenoxy)acetyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone of Example 75 (0.3 mmol), 4-hydroxy-3-methoxybenzylamine hydrochloride (2.2 eq.) and triethylamine (2.4 eq.) in the manner of Example 68, m.p. 167-168° C. MS [(+)ESI, m/z]: 546 [M+H]+
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07691848B2 |
| Quelldatensatz | uspto-grants-2010_04 |
| ORD ID | ord-0fc7c15f27d34b669044c5aa56c91367 |
| Quellennotiz | uspto-grants-2010_04 |