HRID639281

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID165576

4-Aminomethyl-2-methoxyphenol hydrochloride

C8H12ClNO2

结构：Cc1cc(Cl)ccc1OCC(=O)N1Cc2ccc(C(=O)C(Cl)(Cl)Cl)n2Cc2ccccc21

HCID16039295

未命名化合物

PRODUCTS

生成物

结构：COc1cc(CNC(=O)c2ccc3n2Cc2ccccc2N(C(=O)COc2ccc(Cl)cc2C)C3)ccc1O

HCID16039365

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized from 2,2,2-trichloro-1-{10-[(4-chloro-2-methylphenoxy)acetyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone of Example 75 (0.3 mmol), 4-hydroxy-3-methoxybenzylamine hydrochloride (2.2 eq.) and triethylamine (2.4 eq.) in the manner of Example 68, m.p. 167-168° C. MS [(+)ESI, m/z]: 546 [M+H]+

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0fc7c15f27d34b669044c5aa56c91367
来源数据集: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07691848B2
来源说明: uspto-grants-2010_04

反应 SMILES

ClC(Cl)(Cl)[C:3]([C:5]1[N:14]2[C:8]([CH2:9][N:10]([C:19](=[O:30])[CH2:20][O:21][C:22]3[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:23]=3[CH3:29])[C:11]3[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=3[CH2:13]2)=[CH:7][CH:6]=1)=[O:4].Cl.[OH:34][C:35]1[CH:42]=[CH:41][C:38]([CH2:39][NH2:40])=[CH:37][C:36]=1[O:43][CH3:44].C(N(CC)CC)C>>[Cl:28][C:25]1[CH:26]=[CH:27][C:22]([O:21][CH2:20][C:19]([N:10]2[C:11]3[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=3[CH2:13][N:14]3[C:5]([C:3]([NH:40][CH2:39][C:38]4[CH:41]=[CH:42][C:35]([OH:34])=[C:36]([O:43][CH3:44])[CH:37]=4)=[O:4])=[CH:6][CH:7]=[C:8]3[CH2:9]2)=[O:30])=[C:23]([CH3:29])[CH:24]=1