反应详情

The title compound was synthesized in the manner of Example 81 from 2,2,2-trichloro-1-[10-{[(4-bromophenyl)thio]acetyl}-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-yl]-ethanone of Example 80 and 4-aminomethyl-2-methoxyphenol hydrochloride in the presence of with one equivalent of triethylamine, m.p. 168° C. MS [(+)ESI, m/z]: 592 [M+H]+ Anal. Calcd for C29H26BrN3O4S: C, 58.79; H, 4.42; N, 7.09. Found: C, 58.65; H, 4.46; N, 6.86.