Methyl iodide → Methyl 4-bromo-3-methoxythiophene-2-carboxylate

HRID 639292ノート

反応式

HRID 639292 の反応式
[CH3:1][O:2][C:3]([C:5]1[S:6][CH:7]=[C:8]([Br:11])[C:9]=1[OH:10])=[O:4].[C:12](=O)([O-])[O-].[K+].[K+].IC>CC(C)=O>[CH3:1][O:2][C:3]([C:5]1[S:6][CH:7]=[C:8]([Br:11])[C:9]=1[O:10][CH3:12])=[O:4]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 2777611Methyl 4-bromo-3-hydroxythiophene-2-carboxylate

生成物 1

HCID 2736824Methyl 4-bromo-3-methoxythiophene-2-carboxylate収率 129.3%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Methyl-3-hydroxy-4-bromo-2-thiophenecarboxylate (10.0 g, 42.2 mmol) was dissolved in 250 mL of acetone. Potassium carbonate (30.0 g, 217.4 mmol) was added followed by a solution of iodomethane (14.5 mL, 233.0 mmol). The mixture was heated to reflux and continued for 6 h. After cooled to room temperature, the mixture was filtered, the solid material was rinsed with acetone (˜200 mL). The filtrate and rinsing were concentrated under reduced pressure to a solid, further dried on high vacuum, yielding 13.7 g (100%) of methyl-3-methoxy-4-bromo-2-thiophenecarboxylate (MH+=251.0).

後処理

  1. temperatureThe mixture was heated
  2. temperatureto reflux
  3. filtrationthe mixture was filtered
  4. washthe solid material was rinsed with acetone (˜200 mL)
  5. washThe filtrate and rinsing
  6. concentrationwere concentrated under reduced pressure to a solid
  7. customfurther dried on high vacuum

出典と根拠

ORDレコード
ord-c8f7d373f002413bb0b35106e3b9ca66
出典データセット
uspto-grants-2010_04
特許番号
US07691856B2

反応ノート

読み込み中…