反应详情

A mixture of 1 g (4.3 mmol) 5-methanesulfonyloxy-pyrazine-2-carboxylic acid methyl ester and 0.733 (8.6 mmol) piperidine was shaken at room temperature for 4 h. Subsequent purification on silica eluting with a gradient formed from DCM and methanol yielded after evaporation of the product fractions 0.625 g (66%) of the title compound as light yellow crystals. m/z (ES+): 222.0 (M+H).

1. customSubsequent purification on silica eluting with a gradient
2. customformed from DCM and methanol
3. customyielded
4. customafter evaporation of the product fractions 0.625 g (66%) of the title compound as light yellow crystals