反应详情

温度

45 °C

A mixture of 4.9 g (28 mmol) 5-chloro-pyrazine-2-carboxylic acid methyl ester (commercially available), 3.2 g (37 mmol) morpholine and 7.37 g (73 mmol) NEt3 in 50 mL dioxane was heated to 45° C. for 16 h. Water and NaCl aq. was added and the mixture was extracted with ethyl acetate. The combined organic layers were washed with NaCl aq., dried with MgSO4, filtered and evaporated. The residue was recrystallized from ethyl acetate to yield 5.65 g (89%) of the title compound as white solid. m/z (ES+): 224.3 (M+H).

1. extractionthe mixture was extracted with ethyl acetate
2. washThe combined organic layers were washed with NaCl aq.
3. dry with materialdried with MgSO4
4. filtrationfiltered
5. customevaporated
6. customThe residue was recrystallized from ethyl acetate