(4-Bromophenyl)(6-methoxyquinazolin-2-yl)amine → 2-[(4-Bromophenyl)amino]quinazolin-6-ol

HRID 639356Notes

Reaction equation

HRID 639356 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([O:19]C)[CH:15]=3)[N:10]=2)=[CH:4][CH:3]=1>Br>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]2[N:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([OH:19])[CH:15]=3)[N:10]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 59254902(4-Bromophenyl)(6-methoxyquinazolin-2-yl)amine

Product 1

HCID 592548812-[(4-Bromophenyl)amino]quinazolin-6-ol

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

(4-bromophenyl)(6-methoxyquinazolin-2-yl)amine in HBr was heated at 100° C. for 16 hours. The reaction mixture was concentrated and purified on preparative chromatography. Lyophillization yielded 2-[(4-bromophenyl)amino]quinazolin-6-ol.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. custompurified on preparative chromatography

Sources & evidence

ORD record
ord-32c28daa505e4ab9b8da8387ea31e38c
Source dataset
uspto-grants-2010_04
Patent number
US07691866B2

Reaction notes

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