HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 639359Generated: October 26, 2026
N-phenyl-2-naphthylamine → n-Methyl-4-{[2-(naphthalen-2-ylamino)-quinazolin-6-yl]oxy}pyridine-2-carboxamide
https://huagongshe.com/reaction/639359
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-phenyl-2-naphthylamine | HCID 8679 | — |
| Reactant | N-methyl-4-(2-(methylsulfonyl)quinazolin-6-yloxy)picolinamide | HCID 59254867 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | n-Methyl-4-{[2-(naphthalen-2-ylamino)-quinazolin-6-yl]oxy}pyridine-2-carboxamide | HCID 59254846 | — |
Reaction Steps
N-methyl[4-(2-methylsulfonylquinazolin-6-yloxy)(2-pyridyl)]carboxamide 15 (1 eq) was treated with 2-naphthylaniline (2 eq) in acetonitrile (1 M) and heated at 80-85° C. The mixture was evaporated and purified on preparative chromatography to give the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07691866B2 |
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| Source dataset | uspto-grants-2010_04 |
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| ORD ID | ord-283a518dea0649db9cded85a181d7430 |
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| Source note | uspto-grants-2010_04 |
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