3-tert-Butylaniline → (3-tert-Butyl-phenyl)-(6-methoxy-quinoxalin-2-yl)-amine

Participants

Reaction Conditions

Reaction Steps

A solution containing 2-chloro-6-methoxyquinoxaline (synthesized as described in J. Chem. Soc. Perkin Trans 2001, 978-984) (1 eq), 3-t-butylaniline (2 eq) in ethanol was heated at 80° C. overnight. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried. Purification on silica gel gave the desired product.

Provenance & Evidence