Hydrogen Bromide → 2-(3-tert-Butyl-phenylamino)-quinoxalin-6-ol

HRID 639365Notes

Reaction equation

HRID 639365 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([NH:11][C:12]2[CH:21]=[N:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([O:22]C)[CH:18]=3)[N:13]=2)[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].Br>>[C:1]([C:5]1[CH:6]=[C:7]([NH:11][C:12]2[CH:21]=[N:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([OH:22])[CH:18]=3)[N:13]=2)[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 59254854(3-tert-Butyl-phenyl)-(6-methoxy-quinoxalin-2-yl)-amine

Product 1

HCID 1361450542-(3-tert-Butyl-phenylamino)-quinoxalin-6-ol

Procedure

The mixture of (3-tert-Butyl-phenyl)-(6-methoxy-quinoxalin-2-yl)-amine and hydrobromic acid (48%) was subjected to the microwave at 140° C. for 6 mins. to yield the desired product. The mixture was neutralized with sodium bicarbonate solution and taken in ethyl acetate. The organic layer was washed with water and brine, concentrated, and purified on silica gel.

Sources & evidence

ORD record
ord-6820880ed5a74296870402dda3a82ecc
Source dataset
uspto-grants-2010_04
Patent number
US07691866B2

Reaction notes

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