4-Piperidinol, 1-methyl- → HCID 10370484, compound

HRID 639403Notes

Reaction equation

HRID 639403 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]3[CH:18]=[CH:17][N:16]=[C:15]([NH:19][C:20]4[CH:25]=[CH:24][C:23]([CH2:26][N:27]5[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]5)=[CH:22][CH:21]=4)[N:14]=3)=[CH:11][NH:10][N:9]=2)=[CH:4][CH:3]=1.[CH3:34][N:35]1[CH2:40][CH2:39][CH:38](O)[CH2:37][CH2:36]1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]3[CH:18]=[CH:17][N:16]=[C:15]([NH:19][C:20]4[CH:21]=[CH:22][C:23]([CH2:26][N:27]5[CH2:28][CH2:29][N:30]([CH3:33])[CH2:31][CH2:32]5)=[CH:24][CH:25]=4)[N:14]=3)=[CH:11][N:10]([CH:38]3[CH2:39][CH2:40][N:35]([CH3:34])[CH2:36][CH2:37]3)[N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 660484-Piperidinol, 1-methyl-HCID 178480829HCID 178480829, compound

Product 1

HCID 10370484HCID 10370484, compound

Procedure

The title compound is prepared as described in Example 55 starting from {4-[3-(4chloro-phenyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}-[4-(4-methyl-piperazin-1-yl-methyl)-phenyl]-amine (Example 32) and 1-methyl-piperidin-4-ol.

Sources & evidence

ORD record
ord-22785c5eb3c542ae8b2b5b8d44bdd452
Source dataset
uspto-grants-2010_04
Patent number
US07691855B2

Reaction notes

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