1-Bromo-4-nitrobenzene → 4-(4-Ethylpiperazin-1-yl)aniline

HRID 639411Notes

Reaction equation

Br[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][CH:3]=1.[CH2:11]([N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)[CH3:12]>>[CH2:11]([N:13]1[CH2:18][CH2:17][N:16]([C:2]2[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][CH:3]=2)[CH2:15][CH2:14]1)[CH3:12]

Participants

Reactant 2

HCID 114661-Bromo-4-nitrobenzene

HCID 791961-Ethylpiperazine

Product 1

HCID 9367384-(4-Ethylpiperazin-1-yl)aniline

Procedure

4-(4-Ethyl-piperazin-1-yl)-phenylamine is prepared in 2 steps from 1-bromo-4-nitro-benzene and 1-ethyl-piperazine as described in Example 1, Step A and B.

Sources & evidence

ORD record: ord-b6ff310927d64c8cbcd33ef8a364a0e8
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07691855B2

Reaction notes

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