2-Propanesulfonyl chloride → HCID 178461082, compound

HRID 639432Notes

Reaction equation

HRID 639432 reaction equation
[CH:1]([S:4]([NH:7][CH:8]1[CH2:13][CH2:12][CH:11]([C:14](O)=O)[CH2:10][CH2:9]1)(=[O:6])=[O:5])([CH3:3])[CH3:2].NC1CCC(C(OC)=O)CC1.CC(S(Cl)(=O)=O)C.[NH2:35][C:36]1[C:41]([NH2:42])=[CH:40][CH:39]=[C:38]([C:43]2[CH:48]=[CH:47][C:46]([F:49])=[CH:45][C:44]=2[F:50])[N:37]=1>>[F:50][C:44]1[CH:45]=[C:46]([F:49])[CH:47]=[CH:48][C:43]=1[C:38]1[N:37]=[C:36]2[N:35]=[C:14]([C@H:11]3[CH2:12][CH2:13][C@H:8]([NH:7][S:4]([CH:1]([CH3:3])[CH3:2])(=[O:6])=[O:5])[CH2:9][CH2:10]3)[NH:42][C:41]2=[CH:40][CH:39]=1

Participants

5

Reactant 4

HCID 824082-Propanesulfonyl chlorideHCID 422580Methyl 4-aminocyclohexanecarboxylateHCID 23154174HCID 23154174, compoundHCID 23154179HCID 23154179, compound

Product 1

HCID 178461082HCID 178461082, compound

Procedure

4-isopropylsulfonylaminocyclohexanecarboxylic acid as prepared easily from methyl 4-aminocyclohexanecarboxylate with 2-propanesulfonyl chloride, and 2,3-diamino-6-(2,4-difluorophenyl)pyridine were allowed to undergo ring-closure condensation under the same conditions as described in Example 1-3), followed by separatory purification on a collective thin-layer chromatograph (chloroform:methanol=20:1) to give the title compounds.

Workup

  1. customring-closure condensation under the same conditions
  2. customfollowed by separatory purification on a collective thin-layer chromatograph (chloroform:methanol=20:1)

Sources & evidence

ORD record
ord-8ddbb20866014e46b005ce0f0aef57c3
Source dataset
uspto-grants-2010_04
Patent number
US07691860B2

Reaction notes

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